A common and potentially prebiotic activating agent for phosphorylation of nucleosides and oligomerization of nucleotides and amino acids
【研究キーワード】
amino acids / activating chemistry / peptide synthesis / activation chemistry / phosphorylation / polymerization
【研究成果の概要】
The proposed cyanogen chloride induced pathway for the synthesis of RNA and peptides includes: 1. phosphorylation of nucleosides to nucleotides; 2. activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization;3. activation of amino acids to peptides and deprotection. This year, the feasibility of cyanogen chloride activated polymerization of amino acids at step 3 has been demonstrated. It was observed that cyanogen chloride could react with amino acids to afford N-(aminocarbonyl)peptides, and deprotection of the urea group from N-(aminocarbonyl)peptides by NO2 could produce free peptides. These results indicates that the polymerization of RNA (my previous result) and amino acids could occur using cyanogen chloride as activating agent under a single-pot environment.
【研究代表者】
【研究種目】若手研究
【研究期間】2021-04-01 - 2023-03-31
【配分額】2,860千円 (直接経費: 2,200千円、間接経費: 660千円)