マヌカハニー摂取による大腸がん予防機構の解明に向けたニュートリオミクス研究
【研究分野】食品科学
【研究キーワード】
Rice Bran / Gut microbiota / Metabolome / Metagenome / Multi-omics / DSS colitis / AOM DSS colon cancer / Manuka Honey
【研究成果の概要】
In this year, we conducted a screening experiment using different food products (Manuka Honey, Rice Bran and Soy Beans) in the animal models that we have created in last year.Unfortunately, Manuka Homey and Soy Beans supplementation did not improve colitis. As such, we aimed to elucidate the molecular mechanisms of Oryza sativa, rice bran(RB) dietrary intervention on 2.0% dextran sulfate sodium (DSS)-included colitis C57BL/6L mice mode. Body weight loss, disease activity index, colon length and colon histopathology were improved in BR-fed mice. Time-course microbiome and metabolome results suggest that RB-related alterations of gut environment can prevent colitis via establishing gut homeostasis. Our approach is an important tool in developing new therapeutic applications of RB.
【研究代表者】
【研究種目】特別研究員奨励費
【研究期間】2015-11-09 - 2018-03-31
【配分額】2,300千円 (直接経費: 2,300千円)