Isothermal DNA Sequencing by Diffusion Current in a MoS2 Nanopore
【研究分野】生体医工学・生体材料学
【研究キーワード】
Nanopore / DNA sequencing / Bionanosensing / Diffusiophoresis / 2D materials / Joule heating / Diffusion current / Two-dimensional material / Biosensing / 2D material / Ion transport / Electrokinetics / Precision medicine / Drug delivery / ナノチューブ / マイクロ・ナノデバイス / 分析科学 / 生体分子
【研究成果の概要】
It was demonstrated that the structural information of ssDNA molecules can be revealed using artificial solid-state nanopores. The proposed isothermal sensing method by diffusion current has simultaneously resolved the excess DNA translocation speed and high thermal noise issues.
【研究の社会的意義】
This project has made a remarkable progress by increasing the nanopore sensing resolution, which paves the way for DNA sequencing using solid-state nanopores. This breakthrough not only opens up new opportunities for molecule sequencing, but provides hopes to high resolution proteomic analysis.
【研究代表者】
【研究協力者】 |
| 大宮司 啓文 | |
| 岩佐 義宏 | |
| 阿部 英司 | |
| Ying Yi-Lun | |
| Long Yi-Tao | |
|
【研究種目】若手研究(B)
【研究期間】2017-04-01 - 2019-03-31
【配分額】3,900千円 (直接経費: 3,000千円、間接経費: 900千円)